Higher levels of lithium in tap water may be linked to a slightly increased risk of autism diagnosis in children, according to a new study published in the journal JAMA Pediatrics.
Researchers from Denmark analyzed data on more than 8,800 children diagnosed with autism spectrum disorder (ASD) and found that those exposed to higher levels of lithium in their drinking water during pregnancy had an increased risk of ASD. The association was strongest among children born to mothers who consumed large amounts of bottled water.
While the study suggests a possible connection between lithium exposure and ASD, experts say more research is needed to determine whether there is a causal link between the two.
The US Environmental Protection Agency (EPA) has set no federal standards for lithium levels in drinking water. The agency notes that lithium is an essential nutrient found naturally in some foods and can have both beneficial and adverse effects on human health, depending on the concentration.
Previous research has suggested links between ASD and exposure to environmental toxins such as pesticides, air pollution, and phthalates, but none of these studies provide conclusive evidence for a direct causal relationship.
Dr. Beate Ritz, co-author of the study, emphasized that her team's findings do not prove causation, and more research is needed to determine whether lithium exposure plays a role in ASD development.
"It's an interesting association," Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland, said. "But we need to see if there's a viable and biologically plausible mechanism by which a small amount of lithium in the water supply can do this."
Researchers from Denmark analyzed data on more than 8,800 children diagnosed with autism spectrum disorder (ASD) and found that those exposed to higher levels of lithium in their drinking water during pregnancy had an increased risk of ASD. The association was strongest among children born to mothers who consumed large amounts of bottled water.
While the study suggests a possible connection between lithium exposure and ASD, experts say more research is needed to determine whether there is a causal link between the two.
The US Environmental Protection Agency (EPA) has set no federal standards for lithium levels in drinking water. The agency notes that lithium is an essential nutrient found naturally in some foods and can have both beneficial and adverse effects on human health, depending on the concentration.
Previous research has suggested links between ASD and exposure to environmental toxins such as pesticides, air pollution, and phthalates, but none of these studies provide conclusive evidence for a direct causal relationship.
Dr. Beate Ritz, co-author of the study, emphasized that her team's findings do not prove causation, and more research is needed to determine whether lithium exposure plays a role in ASD development.
"It's an interesting association," Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland, said. "But we need to see if there's a viable and biologically plausible mechanism by which a small amount of lithium in the water supply can do this."