Lithium levels in tap water linked to autism diagnosis risk, but experts caution against direct link.
A new study published in JAMA Pediatrics has found a moderate association between higher lithium levels in drinking water and an increased risk of autism spectrum disorder (ASD) in children born to mothers who consumed more of the metal during pregnancy. The research suggests that as lithium concentrations in tap water increased, so did the risk of ASD diagnosis among children.
According to the study's findings, pregnant women who lived in areas with higher levels of lithium in their drinking water had a 24% to 26% higher risk of having a child diagnosed with ASD, while those exposed to the highest levels of lithium had a 46% increased risk. The researchers also found that the association was most pronounced among children born between 2000 and 2013.
The study's lead author, Dr. Beate Ritz, emphasized the need for further research into the potential link between lithium exposure and ASD. "Any drinking water contaminants that may affect the developing human brain deserve intense scrutiny," she said in a news release.
However, other experts have expressed caution against drawing direct conclusions from the study's findings. Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland, noted that higher doses of lithium are commonly used to treat mental health disorders, but there is no evidence linking these treatments to an increased risk of ASD.
"Pharmacologic dosing of lithium in women with bipolar disorder has not been reported to be causing increased risk of ASD," Wiznitzer said. "It's an interesting association, but causation is definitely not proven."
The study's findings have sparked debate about the potential role of environmental factors in the development of ASD. While some research has suggested a link between exposure to pesticides and air pollution and ASD, others have found no conclusive evidence of a causal relationship.
"It's hard to prove that one factor is causing the other," Wiznitzer said. "We're bombarded with various environmental stressors in our everyday lives. We need to figure out how to safely navigate them."
The implications of the study's findings for public health policy are also unclear. Some experts argue that higher levels of lithium in drinking water could have benefits, such as lower rates of hospitalization for psychiatric disorders and suicide.
"The wisdom of Solomon will be required to develop guidelines for lithium in drinking water that are maximally protective of the entire population," Dr. David C. Bellinger, a professor of neurology and psychology at Harvard Medical School, wrote in an editorial accompanying the study.
Ultimately, more research is needed to fully understand the potential relationship between lithium exposure and ASD.
A new study published in JAMA Pediatrics has found a moderate association between higher lithium levels in drinking water and an increased risk of autism spectrum disorder (ASD) in children born to mothers who consumed more of the metal during pregnancy. The research suggests that as lithium concentrations in tap water increased, so did the risk of ASD diagnosis among children.
According to the study's findings, pregnant women who lived in areas with higher levels of lithium in their drinking water had a 24% to 26% higher risk of having a child diagnosed with ASD, while those exposed to the highest levels of lithium had a 46% increased risk. The researchers also found that the association was most pronounced among children born between 2000 and 2013.
The study's lead author, Dr. Beate Ritz, emphasized the need for further research into the potential link between lithium exposure and ASD. "Any drinking water contaminants that may affect the developing human brain deserve intense scrutiny," she said in a news release.
However, other experts have expressed caution against drawing direct conclusions from the study's findings. Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland, noted that higher doses of lithium are commonly used to treat mental health disorders, but there is no evidence linking these treatments to an increased risk of ASD.
"Pharmacologic dosing of lithium in women with bipolar disorder has not been reported to be causing increased risk of ASD," Wiznitzer said. "It's an interesting association, but causation is definitely not proven."
The study's findings have sparked debate about the potential role of environmental factors in the development of ASD. While some research has suggested a link between exposure to pesticides and air pollution and ASD, others have found no conclusive evidence of a causal relationship.
"It's hard to prove that one factor is causing the other," Wiznitzer said. "We're bombarded with various environmental stressors in our everyday lives. We need to figure out how to safely navigate them."
The implications of the study's findings for public health policy are also unclear. Some experts argue that higher levels of lithium in drinking water could have benefits, such as lower rates of hospitalization for psychiatric disorders and suicide.
"The wisdom of Solomon will be required to develop guidelines for lithium in drinking water that are maximally protective of the entire population," Dr. David C. Bellinger, a professor of neurology and psychology at Harvard Medical School, wrote in an editorial accompanying the study.
Ultimately, more research is needed to fully understand the potential relationship between lithium exposure and ASD.