Lithium levels in tap water may be associated with a slightly increased risk of autism spectrum disorder (ASD) diagnosis in children, according to a new study published in the journal JAMA Pediatrics. However, experts caution that this association does not necessarily indicate a direct link between lithium exposure and autism.
The study, which examined data from over 8,800 cases of ASD and 43,000 participants without ASD, found that as lithium levels in water increased, so did the risk of an ASD diagnosis. Specifically, children exposed to higher levels of lithium during pregnancy had a 24% to 26% higher risk of ASD diagnosed compared to those with lower exposure.
However, researchers emphasize that more research is needed to confirm this association and determine whether lithium exposure directly contributes to autism development. "Any drinking water contaminants that may affect the developing human brain deserve intense scrutiny," said Dr. Beate Ritz, a study co-author.
Lithium levels in tap water are not regulated by the US government, and its consumption can vary widely depending on location and source. While some studies suggest potential health benefits of lithium at high doses, such as lower rates of hospitalization for psychiatric disorders and suicide, others have raised concerns about potential risks, including neurological effects.
Dr. Max Wiznitzer, a pediatrician who specializes in autism treatment, notes that research on the effects of lithium on pregnant women with mental health conditions is limited, but suggests that current evidence does not support a causal link between lithium exposure and ASD. "It's an interesting association, but causation is definitely not proven," he said.
The study highlights the complexities of environmental factors in autism development, where it can be challenging to determine whether specific exposures contribute directly to the disorder or if they are simply associated with populations that already live in polluted environments. As Dr. Wiznitzer noted, "There's a lot of speculation about environmental factors, but how many of them are truly causally associated?" Further research is needed to untangle these relationships and inform public health policy.
The study, which examined data from over 8,800 cases of ASD and 43,000 participants without ASD, found that as lithium levels in water increased, so did the risk of an ASD diagnosis. Specifically, children exposed to higher levels of lithium during pregnancy had a 24% to 26% higher risk of ASD diagnosed compared to those with lower exposure.
However, researchers emphasize that more research is needed to confirm this association and determine whether lithium exposure directly contributes to autism development. "Any drinking water contaminants that may affect the developing human brain deserve intense scrutiny," said Dr. Beate Ritz, a study co-author.
Lithium levels in tap water are not regulated by the US government, and its consumption can vary widely depending on location and source. While some studies suggest potential health benefits of lithium at high doses, such as lower rates of hospitalization for psychiatric disorders and suicide, others have raised concerns about potential risks, including neurological effects.
Dr. Max Wiznitzer, a pediatrician who specializes in autism treatment, notes that research on the effects of lithium on pregnant women with mental health conditions is limited, but suggests that current evidence does not support a causal link between lithium exposure and ASD. "It's an interesting association, but causation is definitely not proven," he said.
The study highlights the complexities of environmental factors in autism development, where it can be challenging to determine whether specific exposures contribute directly to the disorder or if they are simply associated with populations that already live in polluted environments. As Dr. Wiznitzer noted, "There's a lot of speculation about environmental factors, but how many of them are truly causally associated?" Further research is needed to untangle these relationships and inform public health policy.