Small amounts of lithium in tap water may be linked to a higher risk of autism spectrum disorder (ASD) in children born to pregnant women, according to a recent study. The research suggests that mothers who consumed more lithium during pregnancy had an increased risk of their child being diagnosed with ASD.
The association between lithium and ASD is small, but it remains a topic of interest for scientists. To date, the exact cause of autism is still unknown, with genetics believed to play a role, although environmental factors such as exposure to certain chemicals have also been proposed as potential causes.
One study published recently in the journal JAMA Pediatrics examined data from Denmark and found that pregnant women who drank more lithium-containing tap water had a higher risk of their child being diagnosed with ASD. The researchers analyzed the levels of lithium in drinking water across 151 public waterworks that served over half the Danish population, mapping where pregnant women lived.
The study revealed a modest increase in risk, with those exposed to higher levels of lithium having a 24% to 26% greater chance of an ASD diagnosis compared to those at lower exposure levels. However, the researchers emphasized that this association does not necessarily imply a direct link between lithium and ASD.
"This is an interesting finding, but causation is definitely not proven," Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland, said. "We have to see if there's a viable and biologically plausible mechanism by which a small amount of lithium in the water supply can somehow do this."
Experts caution that more research is needed to fully understand the potential relationship between lithium exposure during pregnancy and ASD risk. One study examining higher levels of lithium exposure in pregnant women has not shown an increased risk of ASD, although the researchers noted that pharmacologic dosing of lithium in women with bipolar disorder was not linked to a similar risk.
The implications of this association for public health policy are complex. Lithium levels in water associated with a potential ASD risk have also been linked to improved rates of hospitalization for psychiatric disorders and reduced suicide rates, suggesting the need for further study to balance any potential benefits against risks.
Researchers highlight that environmental exposure is often difficult to prove as a direct cause of ASD, citing studies showing increased risk from air pollution but struggling to distinguish between causation and correlation. As Wiznitzer noted, "we are bombarded with a variety of environmental stressors in our everyday lives... we have to figure out how to basically safely navigate them."
The association between lithium and ASD is small, but it remains a topic of interest for scientists. To date, the exact cause of autism is still unknown, with genetics believed to play a role, although environmental factors such as exposure to certain chemicals have also been proposed as potential causes.
One study published recently in the journal JAMA Pediatrics examined data from Denmark and found that pregnant women who drank more lithium-containing tap water had a higher risk of their child being diagnosed with ASD. The researchers analyzed the levels of lithium in drinking water across 151 public waterworks that served over half the Danish population, mapping where pregnant women lived.
The study revealed a modest increase in risk, with those exposed to higher levels of lithium having a 24% to 26% greater chance of an ASD diagnosis compared to those at lower exposure levels. However, the researchers emphasized that this association does not necessarily imply a direct link between lithium and ASD.
"This is an interesting finding, but causation is definitely not proven," Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland, said. "We have to see if there's a viable and biologically plausible mechanism by which a small amount of lithium in the water supply can somehow do this."
Experts caution that more research is needed to fully understand the potential relationship between lithium exposure during pregnancy and ASD risk. One study examining higher levels of lithium exposure in pregnant women has not shown an increased risk of ASD, although the researchers noted that pharmacologic dosing of lithium in women with bipolar disorder was not linked to a similar risk.
The implications of this association for public health policy are complex. Lithium levels in water associated with a potential ASD risk have also been linked to improved rates of hospitalization for psychiatric disorders and reduced suicide rates, suggesting the need for further study to balance any potential benefits against risks.
Researchers highlight that environmental exposure is often difficult to prove as a direct cause of ASD, citing studies showing increased risk from air pollution but struggling to distinguish between causation and correlation. As Wiznitzer noted, "we are bombarded with a variety of environmental stressors in our everyday lives... we have to figure out how to basically safely navigate them."